Target：LI-cadherin

Fields：Gastric cancer

Gene Name：CDH17

Protein Name：Cadherin-17

Human Gene Id：1015

Human Swiss Prot No：Q12864

Mouse Swiss Prot No：Q9R100

Immunogen：The antiserum was produced against synthesized peptide derived from human CDH17. AA range:341-390

Specificity：LI-cadherin Polyclonal Antibody detects endogenous levels of LI-cadherin protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CDH17;Cadherin-17;Intestinal peptide-associated transporter HPT-1;Liver-intestine cadherin;LI-cadherin

Observed Band(KD)：99kD

Background： This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009],

Function：function:Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport.,similarity:Contains 7 cadherin domains.,tissue specificity:Expressed in the gastrointestinal tract and pancreatic duct. Not detected in kidney, lung, liver, brain, adrenal gland and skin.,

Subcellular Location：Cell membrane ; Single-pass type I membrane protein .

Expression：Expressed in the gastrointestinal tract and pancreatic duct. Not detected in kidney, lung, liver, brain, adrenal gland and skin.