Target：LOST1

Gene Name：TUSC5

Protein Name：Tumor suppressor candidate 5

Human Gene Id：286753

Human Swiss Prot No：Q8IXB3

Mouse Swiss Prot No：Q8C838

Immunogen：The antiserum was produced against synthesized peptide derived from human TUSC5. AA range:1-50

Specificity：LOST1 Polyclonal Antibody detects endogenous levels of LOST1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：TUSC5;IFITMD3;LOST1;Tumor suppressor candidate 5;Dispanin subfamily B member 1;DSPB1;Interferon-induced transmembrane domain-containing protein D3;Protein located at seventeen-p-thirteen point three 1

Observed Band(KD)：22kD

Background：developmental stage:Expressed in fetal brain.,function:May be involved in fat metabolism.,similarity:Belongs to the CD225 family.,tissue specificity:Expressed at high levels in heart, mammary gland, adrenal gland, stomach, smooth muscle and skeletal muscle, and at lower levels in brain and lung. Strongly down-regulated in lung cancer tissues, due to hypermethylation of the corresponding locus.,

Function：developmental stage:Expressed in fetal brain.,function:May be involved in fat metabolism.,similarity:Belongs to the CD225 family.,tissue specificity:Expressed at high levels in heart, mammary gland, adrenal gland, stomach, smooth muscle and skeletal muscle, and at lower levels in brain and lung. Strongly down-regulated in lung cancer tissues, due to hypermethylation of the corresponding locus.,

Subcellular Location：Cell membrane ; Single-pass membrane protein . Endomembrane system ; Single-pass membrane protein . Cytoplasm, perinuclear region . Shifts from low-density microsome vesicles to the cell membrane upon insulin stimulation. .

Expression：Expressed at high levels in heart, mammary gland, adrenal gland, stomach, smooth muscle and skeletal muscle, and at lower levels in brain and lung. Strongly down-regulated in lung cancer tissues, due to hypermethylation of the corresponding locus (PubMed:12660825). Expressed in adipose tissue (PubMed:26629404).