Target：LPAAT-γ

Fields：Glycerolipid metabolism;Glycerophospholipid metabolism;Metabolic pathways;Phospholipase D signaling pathway

Gene Name：AGPAT3

Protein Name：1-acyl-sn-glycerol-3-phosphate acyltransferase gamma

Human Gene Id：56894

Human Swiss Prot No：Q9NRZ7

Mouse Gene Id：28169

Mouse Swiss Prot No：Q9D517

Immunogen：The antiserum was produced against synthesized peptide derived from human AGPAT3. AA range:121-170

Specificity：LPAAT-γ Polyclonal Antibody detects endogenous levels of LPAAT-γ protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：AGPAT3;1-acyl-sn-glycerol-3-phosphate acyltransferase gamma;1-acylglycerol-3-phosphate O-acyltransferase 3;1-AGP acyltransferase 3;1-AGPAT 3;Lysophosphatidic acid acyltransferase gamma;LPAAT-gamma

Observed Band(KD)：40kD

Background： The protein encoded by this gene is an acyltransferase that converts lysophosphatidic acid into phosphatidic acid, which is the second step in the de novo phospholipid biosynthetic pathway. The encoded protein may be an integral membrane protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008],

Function：catalytic activity:Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.,domain:The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.,function:Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.,pathway:Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.,similarity:Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.,

Subcellular Location：Endoplasmic reticulum membrane ; Multi-pass membrane protein . Nucleus envelope .

Expression：Widely expressed with highest levels in testis, pancreas and kidney, followed by spleen, lung, adipose tissue and liver.