Target：LPAAT-ε

Fields：Glycerolipid metabolism;Glycerophospholipid metabolism;Metabolic pathways;Phospholipase D signaling pathway

Gene Name：AGPAT5

Protein Name：1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon

Human Gene Id：55326

Human Swiss Prot No：Q9NUQ2

Mouse Swiss Prot No：Q9D1E8

Immunogen：The antiserum was produced against synthesized peptide derived from human AGPAT5. AA range:241-290

Specificity：LPAAT-ε Polyclonal Antibody detects endogenous levels of LPAAT-ε protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：AGPAT5;1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon;1-acylglycerol-3-phosphate O-acyltransferase 5;1-AGP acyltransferase 5;1-AGPAT 5;Lysophosphatidic acid acyltransferase epsilon;LPAAT-epsilon

Observed Band(KD)：45kD

Background： This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. A pseudogene of this gene is present on the Y chromosome. [provided by RefSeq, Aug 2014],

Function：catalytic activity:Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.,caution:It is uncertain whether Met-1 or Met-12 is the initiator.,domain:The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.,function:Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.,pathway:Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.,similarity:Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.,

Subcellular Location：Endoplasmic reticulum membrane ; Multi-pass membrane protein . Nucleus envelope . Mitochondrion .

Expression：Widely expressed.