Target：LPAAT-θ

Fields：Glycerolipid metabolism;Glycerophospholipid metabolism;Metabolic pathways

Gene Name：AGPAT9

Protein Name：Glycerol-3-phosphate acyltransferase 3

Human Gene Id：84803

Human Swiss Prot No：Q53EU6

Mouse Gene Id：231510

Mouse Swiss Prot No：Q8C0N2

Rat Gene Id：305166

Rat Swiss Prot No：Q4V8J4

Immunogen：The antiserum was produced against synthesized peptide derived from human AGPAT9. AA range:381-430

Specificity：LPAAT-θ Polyclonal Antibody detects endogenous levels of LPAAT-θ protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：AGPAT9;GPAT3;MAG1;HMFN0839;Glycerol-3-phosphate acyltransferase 3;GPAT-3;1-acylglycerol-3-phosphate O-acyltransferase 9;1-AGP acyltransferase 9;1-AGPAT 9;Acyl-CoA:glycerol-3-phosphate acyltransferase 3;hGPAT3;Lung cancer metastas

Observed Band(KD)：48kD

Background： This gene encodes a member of the lysophosphatidic acid acyltransferase protein family. The encoded protein is an enzyme which catalyzes the conversion of glycerol-3-phosphate to lysophosphatidic acid in the synthesis of triacylglycerol. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2012],

Function：catalytic activity:Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate.,domain:The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.,enzyme regulation:Inhibited by N-ethylmaleimide (NEM).,function:Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Overexpression activates the mTOR pathway.,pathway:Glycerolipid metabolism; triacylglycerol biosynthesis.,pathway:Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3.,similarity:Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.,tissue specificity:Widely expressed. Expressed in liver, kidney, testis, brain, heart, skeletal muscle, thyroid, prostate, thymus and placenta.

Subcellular Location：Endoplasmic reticulum membrane ; Multi-pass membrane protein .

Expression：Widely expressed. Expressed in liver, kidney, testis, brain, heart, skeletal muscle, thyroid, prostate, thymus and placenta. Also expressed lung and adipose tissue.