Target：Cdc42EP3
Gene Name：CDC42EP3
Protein Name：Cdc42 effector protein 3
Human Gene Id：10602
Human Swiss Prot No：Q9UKI2
Mouse Gene Id：260409
Mouse Swiss Prot No：Q9CQC5
Immunogen：Synthesized peptide derived from the N-terminal region of human Cdc42EP3.
Specificity：Cdc42EP3 Polyclonal Antibody detects endogenous levels of Cdc42EP3 protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：CDC42EP3;BORG2;CEP3;Cdc42 effector protein 3;Binder of Rho GTPases 2;MSE55-related Cdc42-binding protein
Observed Band(KD)：26kD
Background： This gene encodes a member of a small family of guanosine triphosphate (GTP) metabolizing proteins that contain a CRIB (Cdc42, Rac interactive binding) domain. Members of this family of proteins act as effectors of CDC42 function. The encoded protein is involved in actin cytoskeleton re-organization during cell shape changes, including pseudopodia formation. A pseudogene of this gene is found on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012],
Function：function:Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts.,similarity:Belongs to the BORG/CEP family.,similarity:Contains 1 CRIB domain.,subunit:Interacts with RHOQ and CDC42, in a GTP-dependent manner, and with SEPT7.,tissue specificity:Highly expressed in the heart and weakly in the brain.,
Subcellular Location：Endomembrane system ; Peripheral membrane protein . Cytoplasm, cytoskeleton .
Expression：Highly expressed in the heart and weakly in the brain.
