Target：Cdc42EP2
Gene Name：CDC42EP2
Protein Name：Cdc42 effector protein 2
Human Gene Id：10435
Human Swiss Prot No：O14613
Mouse Gene Id：104252
Mouse Swiss Prot No：Q8JZX9
Rat Gene Id：309175
Rat Swiss Prot No：Q5PQP4
Immunogen：The antiserum was produced against synthesized peptide derived from human BORG1. AA range:10-59
Specificity：Cdc42EP2 Polyclonal Antibody detects endogenous levels of Cdc42EP2 protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：CDC42EP2;BORG1;CEP2;Cdc42 effector protein 2;Binder of Rho GTPases 1
Observed Band(KD)：28kD
Background： CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of CDC42. Coexpression of this protein with CDC42 suggested a role of this protein in actin filament assembly and cell shape control. [provided by RefSeq, Aug 2011],
Function：domain:The CRIB domain mediates interaction with CDC42.,function:Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner.,similarity:Belongs to the BORG/CEP family.,similarity:Contains 1 CRIB domain.,subunit:Interacts with RHOQ and CDC42 in a GTP-dependent manner, and with SEPT7.,tissue specificity:Highly expressed in the heart. Weakly expressed in the pancreas and liver.,
Subcellular Location：Endomembrane system ; Peripheral membrane protein . Cytoplasm, cytoskeleton .
Expression：Highly expressed in the heart. Weakly expressed in the pancreas and liver.
