Target：Cdc37

Fields：PI3K-Akt signaling pathway

Gene Name：CDC37

Protein Name：Hsp90 co-chaperone Cdc37

Human Gene Id：11140

Human Swiss Prot No：Q16543

Mouse Gene Id：12539

Mouse Swiss Prot No：Q61081

Rat Gene Id：114562

Rat Swiss Prot No：Q63692

Immunogen：The antiserum was produced against synthesized peptide derived from human CDC37. AA range:1-50

Specificity：Cdc37 Polyclonal Antibody detects endogenous levels of Cdc37 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CDC37;CDC37A;Hsp90 co-chaperone Cdc37;Hsp90 chaperone protein kinase-targeting subunit;p50Cdc37

Observed Band(KD)：44kD

Background： The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. [provided by RefSeq, Jul 2008],

Function：function:Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity.,PTM:Constitutively sumoylated by UBE2I.,similarity:Belongs to the CDC37 family.,subunit:Forms a complex with Hsp90. Interacts with AR, CDK4, CDK6, EIF2AK1 and RB1.,

Subcellular Location：Cytoplasm .

Expression： Lymph,Placenta,