Target：Cdc23

Fields：Cell cycle;Oocyte meiosis;Ubiquitin mediated proteolysis;Progesterone-mediated oocyte maturation;Human T-cell leukemia virus 1 infection

Gene Name：CDC23

Protein Name：Cell division cycle protein 23 homolog

Human Gene Id：8697

Human Swiss Prot No：Q9UJX2

Mouse Gene Id：52563

Mouse Swiss Prot No：Q8BGZ4

Immunogen：The antiserum was produced against synthesized peptide derived from human APC8. AA range:251-300

Specificity：Cdc23 Polyclonal Antibody detects endogenous levels of Cdc23 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CDC23;ANAPC8;Cell division cycle protein 23 homolog;Anaphase-promoting complex subunit 8;APC8;Cyclosome subunit 8

Observed Band(KD)：69kD

Background： The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. [provided by RefSeq, Jul 2008],

Function：function:Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.,pathway:Protein modification; protein ubiquitination.,PTM:Phosphorylated. Phosphorylation on Thr-556 occurs specifically during mitosis.,similarity:Belongs to the APC8/CDC23 family.,similarity:Contains 9 TPR repeats.,subunit:The APC/C is composed of at least 11 subunits.,

Subcellular Location：intracellular,nucleoplasm,anaphase-promoting complex,cytosol,

Expression： Bone marrow,Brain,Duodenum,Epithelium,Pancreas,Placenta,