Target：Cdc16

Fields：Cell cycle;Oocyte meiosis;Ubiquitin mediated proteolysis;Progesterone-mediated oocyte maturation;Human T-cell leukemia virus 1 infection

Gene Name：CDC16

Protein Name：Cell division cycle protein 16 homolog

Human Gene Id：8881

Human Swiss Prot No：Q13042

Mouse Gene Id：69957

Mouse Swiss Prot No：Q8R349

Immunogen：The antiserum was produced against synthesized peptide derived from human APC6. AA range:181-230

Specificity：Cdc16 Polyclonal Antibody detects endogenous levels of Cdc16 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CDC16;ANAPC6;Cell division cycle protein 16 homolog;Anaphase-promoting complex subunit 6;APC6;CDC16 homolog;CDC16Hs;Cyclosome subunit 6

Observed Band(KD)：72kD

Background： The protein encoded by this gene functions as a protein ubiquitin ligase and is a component of the multiprotein APC complex. The APC complex is a cyclin degradation system that governs exit from mitosis by targeting cell cycle proteins for degredation by the 26S proteasome. Each component protein of the APC complex is highly conserved among eukaryotic organisms. This protein, and other APC complex proteins, contain a tetratricopeptide repeat (TPR) domain; a protein domain that is often involved in protein-protein interactions and the assembly of multiprotein complexes. Multiple alternatively spliced transcript variants, encoding distinct proteins, have been identified. [provided by RefSeq, Jan 2016],

Function：function:Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.,pathway:Protein modification; protein ubiquitination.,PTM:Phosphorylated. Phosphorylation on Ser-560 occurs specifically during mitosis.,similarity:Belongs to the APC6/CDC16 family.,similarity:Contains 7 TPR repeats.,subcellular location:Colocalizes with CDC27 to the centrosome at all stages of the cell cycle and to the mitotic spindle.,subunit:The APC/C is composed of at least 11 subunits. Interacts with PPP5C and CDC20.,

Subcellular Location：Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle . Colocalizes with CDC27 to the centrosome at all stages of the cell cycle and to the mitotic spindle.

Expression： Aorta endothelial cell,Brain,Epithelium,Lung,Skin,