Target：CDA7L

Gene Name：CDCA7L HR1 JPO2 R1

Protein Name：Cell division cycle-associated 7-like protein (Protein JPO2) (Transcription factor RAM2)

Human Gene Id：55536

Human Swiss Prot No：Q96GN5

Mouse Swiss Prot No：Q922M5

Rat Swiss Prot No：Q4G059

Immunogen：Synthesized peptide derived from human protein . at AA range: 140-220

Specificity：CDA7L Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：49kD

Background：function:Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1.,induction:By MYC overexpression in a concentration dependent manner in neuroblastoma cell line.,miscellaneous:Cells lacking CDCA7L display a reduction of 25-30% of colony formation in medulloblastoma cell lines. CDCA7L overexpression induces colony formation.,subcellular location:Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction.,subunit:Interacts with MYC and PSIP1.,tissue specificity:Ubiquitous. Overexpressed in medulloblastoma.,

Function：function:Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1.,induction:By MYC overexpression in a concentration dependent manner in neuroblastoma cell line.,miscellaneous:Cells lacking CDCA7L display a reduction of 25-30% of colony formation in medulloblastoma cell lines. CDCA7L overexpression induces colony formation.,subcellular location:Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction.,subunit:Interacts with MYC and PSIP1.,tissue specificity:Ubiquitous. Overexpressed in medullo

Subcellular Location：Cytoplasm. Nucleus. Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction.

Expression：Ubiquitous. Overexpressed in medulloblastoma.