Target：Glycogen Synthase 1

Fields：Starch and sucrose metabolism;Metabolic pathways;PI3K-Akt signaling pathway;AMPK signaling pathway;Insulin signaling pathway;Glucagon signaling pathway;Insulin resistance;Diabetic cardiomyopathy

Gene Name：GYS1

Protein Name：Glycogen [starch] synthase muscle

Human Gene Id：2997

Human Swiss Prot No：P13807

Mouse Gene Id：14936

Mouse Swiss Prot No：Q9Z1E4

Rat Gene Id：690987

Rat Swiss Prot No：A2RRU1

Immunogen：The antiserum was produced against synthesized peptide derived from human Glycogen Synthase. AA range:621-670

Specificity：Glycogen Synthase 1 Polyclonal Antibody detects endogenous levels of Glycogen Synthase 1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:10000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：GYS1;GYS;Glycogen [starch] synthase; muscle

Observed Band(KD)：85kD

Background： The protein encoded by this gene catalyzes the addition of glucose monomers to the growing glycogen molecule through the formation of alpha-1,4-glycoside linkages. Mutations in this gene are associated with muscle glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009],

Function：catalytic activity:UDP-glucose ((1->4)-alpha-D-glucosyl)(n) = UDP + ((1->4)-alpha-D-glucosyl)(n+1).,disease:Defects in GYS1 are the cause of muscle glycogen storage disease type 0 (GSD0b) [MIM:611556]; also called muscle glycogen synthase deficiency. GSD0 is a metabolic disorder characterized by fasting hypoglycemia presenting in infancy or early childhood. The role of muscle glycogen is to provide critical energy during bursts of activity and sustained muscle work.,enzyme regulation:Allosteric activation by glucose-6-phosphate. Phosphorylation reduces the activity towards UDP-glucose. When in the non-phosphorylated state, glycogen synthase does not require glucose-6-phosphate as an allosteric activator; when phosphorylated it does.,function:Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.,pathway:Glycan biosynthesis; glycogen biosynthesis.,similar

Subcellular Location：cytosol,membrane,inclusion body,

Expression： Endometrium,Heart,Kidney,Lymph,Muscle,Skin,