Target：RNF138

Gene Name：RNF138

Protein Name：E3 ubiquitin-protein ligase RNF138

Human Gene Id：51444

Human Swiss Prot No：Q8WVD3

Mouse Gene Id：56515

Mouse Swiss Prot No：Q9CQE0

Rat Gene Id：94196

Rat Swiss Prot No：Q99PD2

Immunogen：The antiserum was produced against synthesized peptide derived from human RNF138. AA range:31-80

Specificity：RNF138 Polyclonal Antibody detects endogenous levels of RNF138 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：RNF138;NARF;HSD-4;HSD4;E3 ubiquitin-protein ligase RNF138;Nemo-like kinase-associated RING finger protein;NLK-associated RING finger protein;hNARF;RING finger protein 138

Observed Band(KD)：28kD

Background：ring finger protein 138(RNF138) Homo sapiens The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008],

Function：domain:The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.,function:E3 ubiquitin-protein ligase. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway.,pathway:Protein modification; protein ubiquitination.,PTM:Auto-ubiquitinated.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 RING-type zinc finger.,subunit:Interacts with nlk.,

Subcellular Location：Chromosome . Recruited at DNA damage sites (PubMed:26502055). Localizes to sites of double-strand break: localization to double-strand break sites is mediated by the zinc fingers (PubMed:26502055, PubMed:26502057). .

Expression： Placenta,Testis,Uterus,