Target：DKK2

Fields：Wnt signaling pathway;Alzheimer disease;Pathways of neurodegeneration - multiple diseases

Gene Name：DKK2 UNQ682/PRO1316

Protein Name：Dickkopf-related protein 2 (Dickkopf-2) (Dkk-2) (hDkk-2)

Human Gene Id：27123

Human Swiss Prot No：Q9UBU2

Mouse Swiss Prot No：Q9QYZ8

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：DKK2 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：28kD

Background： This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). [provided by RefSeq, Jul 2008],

Function：function:Inhibitor of Wnt signaling pathway .,PTM:May be proteolytically processed by a furin-like protease.,similarity:Belongs to the dickkopf family.,tissue specificity:Expressed in heart, brain, skeletal muscle and lung.,

Subcellular Location：Secreted.

Expression：Expressed in heart, brain, skeletal muscle and lung.