Target：Dkk-1

Fields：Wnt signaling pathway;Alzheimer disease;Pathways of neurodegeneration - multiple diseases

Gene Name：DKK1

Protein Name：Dickkopf-related protein 1

Human Gene Id：22943

Human Swiss Prot No：O94907

Mouse Gene Id：13380

Mouse Swiss Prot No：O54908

Immunogen：The antiserum was produced against synthesized peptide derived from the C-terminal region of human DKK1. AA range:181-230

Specificity：Dkk-1 Polyclonal Antibody detects endogenous levels of Dkk-1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:10000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：DKK1;Dickkopf-related protein 1;Dickkopf-1;Dkk-1;hDkk-1;SK

Observed Band(KD)：29kD

Background： This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma. [provided by RefSeq, Jul 2008],

Function：function:Inhibitor of Wnt signaling pathway.,similarity:Belongs to the dickkopf family.,tissue specificity:Placenta.,

Subcellular Location：Secreted.

Expression：Placenta.