Target：DISP1

Fields：Hedgehog signaling pathway

Gene Name：DISP1 DISPA

Protein Name：Protein dispatched homolog 1

Human Gene Id：84976

Human Swiss Prot No：Q96F81

Mouse Swiss Prot No：Q3TDN0

Immunogen：Synthesized peptide derived from human protein . at AA range: 270-350

Specificity：DISP1 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：167kD

Background： The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A novel segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched and, based on sequence identity to its mouse counterpart, the encoded protein may play an essential role in Hh patterning activities in the early embryo. [provided by RefSeq, Jul 2008],

Function：function:Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the dispatched family.,similarity:Contains 1 SSD (sterol-sensing) domain.,

Subcellular Location：Membrane ; Multi-pass membrane protein .

Expression： Colon,Kidney,Kidney epithelium,Muscle,Placenta,Testis,