Target：DIRC2

Gene Name：DIRC2

Protein Name：Disrupted in renal carcinoma protein 2 (Disrupted in renal cancer protein 2)

Human Gene Id：84925

Human Swiss Prot No：Q96SL1

Mouse Swiss Prot No：Q8BFQ6

Rat Swiss Prot No：Q66H95

Immunogen：Synthesized peptide derived from human protein . at AA range: 170-250

Specificity：DIRC2 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：52kD

Background： This gene encodes a membrane-bound protein from the major facilitator superfamily of transporters. Disruption of this gene by translocation has been associated with haplo-insufficiency and renal cell carcinomas. Alternatively spliced transcript variants have been described, but their biological validity has not yet been determined. [provided by RefSeq, Jul 2008],

Function：disease:A chromosomal aberration involving DIRC2 is found in familial renal cell carcinoma 1 (RCC1) [MIM:144700]. Translocation t(2;3)(q35;q21).,similarity:Belongs to the major facilitator superfamily.,tissue specificity:Ubiquitous. Expressed in proximal tubular cells of the kidney.,

Subcellular Location：Lysosome membrane ; Multi-pass membrane protein .

Expression：Ubiquitous. Expressed in proximal tubular cells of the kidney.