Target：FGF-6

Fields：MAPK signaling pathway;Ras signaling pathway;Rap1 signaling pathway;Calcium signaling pathway;PI3K-Akt signaling pathway;Regulation of actin cytoskeleton;Pathways in cancer;Chemical carcinogenesis - receptor activation;Melanoma;Breast cancer;Gastric cancer

Gene Name：FGF6

Protein Name：Fibroblast growth factor 6

Human Gene Id：2251

Human Swiss Prot No：P10767

Mouse Gene Id：14177

Mouse Swiss Prot No：P21658

Immunogen：The antiserum was produced against synthesized peptide derived from the C-terminal region of human FGF6. AA range:159-208

Specificity：FGF-6 Polyclonal Antibody detects endogenous levels of FGF-6 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：FGF6;HST2;HSTF2;Fibroblast growth factor 6;FGF-6;Heparin secretory-transforming protein 2;HST-2;HSTF-2;Heparin-binding growth factor 6;HBGF-6

Observed Band(KD)：23kD

Background： The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene displayed oncogenic transforming activity when transfected into mammalian cells. The mouse homolog of this gene exhibits a restricted expression profile predominantly in the myogenic lineage, which suggested a role in muscle regeneration or differentiation. [provided by RefSeq, Jul 2008],

Function：function:Can transform NIH 3T3 cells. Exhibits strong mitogenic and angiogenic properties.,similarity:Belongs to the heparin-binding growth factors family.,tissue specificity:Leukemia cell lines with platelet/ megakaryocytic differentiation potential.,

Subcellular Location：Secreted, extracellular space.

Expression：Leukemia cell lines with platelet/ megakaryocytic differentiation potential.