Target：FGF-5

Fields：MAPK signaling pathway;Ras signaling pathway;Rap1 signaling pathway;Calcium signaling pathway;PI3K-Akt signaling pathway;Regulation of actin cytoskeleton;Pathways in cancer;Chemical carcinogenesis - receptor activation;Melanoma;Breast cancer;Gastric cancer

Gene Name：FGF5

Protein Name：Fibroblast growth factor 5

Human Gene Id：2250

Human Swiss Prot No：P12034

Mouse Swiss Prot No：P15656

Immunogen：The antiserum was produced against synthesized peptide derived from the C-terminal region of human FGF5. AA range:211-260

Specificity：FGF-5 Polyclonal Antibody detects endogenous levels of FGF-5 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：FGF5;Fibroblast growth factor 5;FGF-5;Heparin-binding growth factor 5;HBGF-5;Smag-82

Observed Band(KD)：30kD

Background： The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified as an oncogene, which confers transforming potential when transfected into mammalian cells. Targeted disruption of the homolog of this gene in mouse resulted in the phenotype of abnormally long hair, which suggested a function as an inhibitor of hair elongation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],

Function：developmental stage:Can transform NIH 3T3 cells.,function:Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase.,similarity:Belongs to the heparin-binding growth factors family.,tissue specificity:Expressed in neonatal brain.,

Subcellular Location：Secreted .

Expression：Expressed in neonatal brain.