Target：FCRL1

Gene Name：FCRL1 FCRH1 IFGP1 IRTA5

Protein Name：Fc receptor-like protein 1 (FcR-like protein 1) (FcRL1) (Fc receptor homolog 1) (FcRH1) (IFGP family protein 1) (hIFGP1) (Immune receptor translocation-associated protein 5) (CD antigen CD307a)

Human Gene Id：115350

Human Swiss Prot No：Q96LA6

Mouse Swiss Prot No：Q8R4Y0

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：FCRL1 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：47kD

Background： This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains three extracellular C2-like immunoglobulin domains, a transmembrane domain and a cytoplasmic domain with two immunoreceptor-tyrosine activation motifs. This protein may play a role in the regulation of cancer cell growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009],

Function：function:May function as an activating coreceptor in B cells. May function in B cells activation and differentiation.,induction:Down-regulated in activated B cells.,PTM:Phosphorylated on tyrosines upon activation.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,tissue specificity:Primarily expressed in secondary lymphoid tissues by mature subsets of B cells. Detected in spleen, lymph node, heart, skeletal muscle, kidney, liver and placenta. Specifically expressed by mature B lineage cells with higher expression in naive versus memory B cells (at protein level).,

Subcellular Location：Cell membrane ; Single-pass type I membrane protein .

Expression：Primarily expressed in secondary lymphoid tissues by mature subsets of B-cells. Detected in spleen, lymph node, heart, skeletal muscle, kidney, liver and placenta. Specifically expressed by mature B lineage cells with higher expression in naive versus memory B-cells (at protein level).