Target：MYO10

Fields：Fc gamma R-mediated phagocytosis;Pathogenic Escherichia coli infection

Gene Name：MYO10 KIAA0799

Protein Name：Unconventional myosin-X (Unconventional myosin-10)

Human Gene Id：4651

Human Swiss Prot No：Q9HD67

Mouse Swiss Prot No：F8VQB6

Rat Swiss Prot No：D3ZJP6

Immunogen：Synthesized peptide derived from human protein . at AA range: 680-760

Specificity：MYO10 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：226kD

Background：myosin X(MYO10) Homo sapiens This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-10 (MYH10). Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. This gene functions as an actin-based molecular motor and plays a role in integration of F-actin and microtubule cytoskeletons during meiosis. [provided by RefSeq, Dec 2011],

Function：function:Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). Plays a role in regions of dynamic actin.,similarity:Contains 1 FERM domain.,similarity:Contains 1 myosin head-like domain.,similarity:Contains 1 MyTH4 domain.,similarity:Contains 2 PH domains.,similarity:Contains 3 IQ domains.,

Subcellular Location：Cytoplasm, cytosol . Cell projection, lamellipodium . Cell projection, ruffle . Cytoplasm, cytoskeleton . Cell projection, filopodium tip . Cytoplasm, cell cortex . Cell projection, filopodium membrane ; Peripheral membrane protein . May be in an inactive, monomeric conformation in the cytosol. Detected in cytoplasmic punctae and in cell projections. Colocalizes with actin fibers. Undergoes forward and rearward movements within filopodia. Interacts with microtubules.

Expression：Ubiquitous.