Target：Musculin

Gene Name：MSC

Protein Name：Musculin

Human Gene Id：9242

Human Swiss Prot No：O60682

Mouse Gene Id：17681

Mouse Swiss Prot No：O88940

Immunogen：The antiserum was produced against synthesized peptide derived from human Musculin. AA range:131-180

Specificity：Musculin Polyclonal Antibody detects endogenous levels of Musculin protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：MSC;ABF1;BHLHA22;Musculin;Activated B-cell factor 1;ABF-1;Class A basic helix-loop-helix protein 22;bHLHa22

Observed Band(KD)：22kD

Background： The protein encoded by this gene is a transcriptional repressor capable of binding an E-box element either as a homodimer or as a heterodimer with E2A in vitro. The encoded protein also forms heterodimers with E2A proteins in vivo. This protein is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian cells. This gene is a downstream target of the B-cell receptor signal transduction pathway. [provided by RefSeq, Jul 2008],

Function：function:Transcription repressor capable of inhibiting the transactivation capability of TCF3/E47. May play a role in regulating antigen-dependent B-cell differentiation.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer. Forms a heterodimer with TCF3.,tissue specificity:Expressed in lymphoid tissues, B-cell lines and activated B-cells.,

Subcellular Location：Nucleus.

Expression：Expressed in lymphoid tissues, B-cell lines and activated B-cells.