Target：MYL2

Fields：Cardiac muscle contraction;Adrenergic signaling in cardiomyocytes;Apelin signaling pathway;Focal adhesion;Tight junction;Leukocyte transendothelial migration;Regulation of actin cytoskeleton;Shigellosis;Salmonella infection;Hypertrophic cardiomyopathy;Dilated cardiomyopathy

Gene Name：MYL2

Protein Name：MYL2

Human Gene Id：4633

Human Swiss Prot No：P10916

Mouse Gene Id：17906

Mouse Swiss Prot No：P51667

Immunogen：Synthesized peptide derived from human MYL2. at AA range: 91-140

Specificity：MYL2 Polyclonal Antibody detects endogenous levels of MYL2

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC-2) (MLC-2v)

Observed Band(KD)：18kD

Background： Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008],

Function：disease:Defects in MYL2 are the cause of cardiomyopathy familial hypertrophic type 10 (CMH10) [MIM:608758]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.,disease:Defects in MYL2 are the cause of cardiomyopathy hypertrophic with mid-left ventricular chamber type 2 (MVC2) [MIM:608758]. MVC2 is a very rare variant of familial hypertrophic cardiomyopathy, characterized by mid-left ventricular chamber thickening.,miscellaneous:This chain binds calcium.,similarity:Contains 3 EF-hand doma

Subcellular Location：Cytoplasm, myofibril, sarcomere, A band .

Expression：Highly expressed in type I muscle fibers.