Target：N33

Fields：N-Glycan biosynthesis;Various types of N-glycan biosynthesis;Metabolic pathways;Protein processing in endoplasmic reticulum

Gene Name：TUSC3

Protein Name：Tumor suppressor candidate 3

Human Gene Id：7991

Human Swiss Prot No：Q13454

Mouse Gene Id：80286

Mouse Swiss Prot No：Q8BTV1

Immunogen：The antiserum was produced against synthesized peptide derived from human TUSC3. AA range:131-180

Specificity：N33 Polyclonal Antibody detects endogenous levels of N33 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：TUSC3;N33;Tumor suppressor candidate 3;Magnesium uptake/transporter TUSC3;Protein N33

Observed Band(KD)：39kD

Background： This gene is a candidate tumor suppressor gene. It is located within a homozygously deleted region of a metastatic prostate cancer. The gene is expressed in most nonlymphoid human tissues including prostate, lung, liver, and colon. Expression was also detected in many epithelial tumor cell lines. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008],

Function：disease:Defects in TUSC3 are the cause of mental retardation non-syndromic autosomal recessive type 7 (MRT7) [MIM:611093]. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.,function:May be involved in N-glycosylation through its association with N-oligosaccharyl transferase.,similarity:Belongs to the OST3/OST6 family.,subunit:Weakly associates with the oligosaccharyl transferase (OST) complex which contains at least RPN1/ribophorin I, RPN2/ribophorin II, OST48, DAD1, and either STT3A or STT3B.,tissue specificity:Expressed in most non-lymphoid cells and tissues examined, including prostate, lung, liver, colon, heart, kidney and pancreas.,

Subcellular Location：Endoplasmic reticulum membrane ; Multi-pass membrane protein .

Expression：Expressed in most non-lymphoid cells and tissues examined, including prostate, lung, liver, colon, heart, kidney and pancreas.