Target：MRP-L41

Gene Name：MRPL41

Protein Name：39S ribosomal protein L41 mitochondrial

Human Gene Id：64975

Human Swiss Prot No：Q8IXM3

Mouse Gene Id：107733

Mouse Swiss Prot No：Q9CQN7

Rat Gene Id：296551

Rat Swiss Prot No：Q5BJX1

Immunogen：The antiserum was produced against synthesized peptide derived from human MRPL41. AA range:81-130

Specificity：MRP-L41 Polyclonal Antibody detects endogenous levels of MRP-L41 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：MRPL41;BMRP;MRPL27;RPML27;PIG3;39S ribosomal protein L41; mitochondrial;L41mt;MRP-L41;39S ribosomal protein L27 homolog;Bcl-2-interacting mitochondrial ribosomal protein L41;Cell proliferation-inducing gene 3 protein;MRP-L27 homo

Observed Band(KD)：21kD

Background： Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the YmL27 ribosomal protein family. [provided by RefSeq, Jul 2008],

Function：function:Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances TP53/p53 stability, thereby contributing to TP53/p53-induced apoptosis in response to growth-inhibitory condition. Enhances TP53/p53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins.,similarity:Belongs to the ribosomal protein L41 family.,subunit:Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Interacts with BCL2.,tissue specificity:Present in kidney, liver, thymus and testis, and at lower level in brain and spleen (at protein level).,

Subcellular Location：Mitochondrion .

Expression：Present in kidney, liver, thymus and testis, and at lower level in brain and spleen (at protein level).