Target:MRP-L41
Gene Name:MRPL41
Protein Name:39S ribosomal protein L41 mitochondrial
Human Gene Id:64975
Human Swiss Prot No:Q8IXM3
Mouse Gene Id:107733
Mouse Swiss Prot No:Q9CQN7
Rat Gene Id:296551
Rat Swiss Prot No:Q5BJX1
Immunogen:The antiserum was produced against synthesized peptide derived from human MRPL41. AA range:81-130
Specificity:MRP-L41 Polyclonal Antibody detects endogenous levels of MRP-L41 protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:MRPL41;BMRP;MRPL27;RPML27;PIG3;39S ribosomal protein L41; mitochondrial;L41mt;MRP-L41;39S ribosomal protein L27 homolog;Bcl-2-interacting mitochondrial ribosomal protein L41;Cell proliferation-inducing gene 3 protein;MRP-L27 homo
Observed Band(KD):21kD
Background: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the YmL27 ribosomal protein family. [provided by RefSeq, Jul 2008],
Function:function:Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances TP53/p53 stability, thereby contributing to TP53/p53-induced apoptosis in response to growth-inhibitory condition. Enhances TP53/p53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins.,similarity:Belongs to the ribosomal protein L41 family.,subunit:Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Interacts with BCL2.,tissue specificity:Present in kidney, liver, thymus and testis, and at lower level in brain and spleen (at protein level).,
Subcellular Location:Mitochondrion .
Expression:Present in kidney, liver, thymus and testis, and at lower level in brain and spleen (at protein level).