Target：ADAMTS-19

Gene Name：ADAMTS19

Protein Name：A disintegrin and metalloproteinase with thrombospondin motifs 19

Human Gene Id：171019

Human Swiss Prot No：Q8TE59

Mouse Gene Id：240322

Mouse Swiss Prot No：P59509

Immunogen：The antiserum was produced against synthesized peptide derived from human ADAMTS19. AA range:251-300

Specificity：ADAMTS-19 Polyclonal Antibody detects endogenous levels of ADAMTS-19 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ADAMTS19;A disintegrin and metalloproteinase with thrombospondin motifs 19;ADAM-TS 19;ADAM-TS19;ADAMTS-19

Observed Band(KD)：140kD

Background： This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has high sequence similarity to the protein encoded by ADAMTS16, another family member. [provided by RefSeq, Jul 2008],

Function：cofactor:Binds 1 zinc ion per subunit.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,PTM:The precursor is cleaved by a furin endopeptidase.,similarity:Contains 1 disintegrin domain.,similarity:Contains 1 peptidase M12B domain.,similarity:Contains 1 PLAC domain.,similarity:Contains 5 TSP type-1 domains.,tissue specificity:Expressed in fetal lung, but not in any adult tissues examined. Expression was detected in an osteosarcoma cDNA library.,

Subcellular Location：Secreted, extracellular space, extracellular matrix .

Expression：Expressed in fetal lung, but not in any adult tissues examined. Expression was detected in an osteosarcoma cDNA library.