Target：ADAMTS-18

Gene Name：ADAMTS18

Protein Name：A disintegrin and metalloproteinase with thrombospondin motifs 18

Human Gene Id：170692

Human Swiss Prot No：Q8TE60

Mouse Gene Id：208936

Mouse Swiss Prot No：Q4VC17

Immunogen：Synthesized peptide derived from ADAMTS-18 . at AA range: 1030-1110

Specificity：ADAMTS-18 Polyclonal Antibody detects endogenous levels of ADAMTS-18 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:10000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ADAMTS18;ADAMTS21;A disintegrin and metalloproteinase with thrombospondin motifs 18;ADAM-TS 18;ADAM-TS18;ADAMTS-18

Observed Band(KD)：135kD

Background： This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protein, which may regulate hemostatic balance and function as a tumor suppressor. Mutations in this gene may be associated with microcornea, myopic chorioretinal atrophy, and telecanthus (MMCAT) and cone-rod dystrophy in human patients. [provided by RefSeq, May 2016],

Function：cofactor:Binds 1 zinc ion per subunit.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,PTM:The precursor is cleaved by a furin endopeptidase.,similarity:Contains 1 disintegrin domain.,similarity:Contains 1 peptidase M12B domain.,similarity:Contains 1 PLAC domain.,similarity:Contains 5 TSP type-1 domains.,tissue specificity:Expressed in fetal lung, liver, and kidney and in adult brain, prostate, submaxillary gland, and endothelium.,

Subcellular Location：Secreted, extracellular space, extracellular matrix .

Expression：Expressed in fetal lung, liver, and kidney and in adult brain, prostate, submaxillary gland, and endothelium.