Target：MRP7
Fields：ABC transporters
Gene Name：ABCC10
Protein Name：Multidrug resistance-associated protein 7
Human Gene Id：89845
Human Swiss Prot No：Q5T3U5
Mouse Swiss Prot No：Q8R4P9
Immunogen：The antiserum was produced against synthesized peptide derived from human MRP7. AA range:835-884
Specificity：MRP7 Polyclonal Antibody detects endogenous levels of MRP7 protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500-2000;IHC 1:50-300
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：ABCC10;MRP7;SIMRP7;Multidrug resistance-associated protein 7;ATP-binding cassette sub-family C member 10
Observed Band(KD)：162kD
Background： The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2010],
Function：function:ATP-dependent transporter probably involved in cellular detoxification through lipophilic anion extrusion.,similarity:Belongs to the ABC transporter family.,similarity:Belongs to the ABC transporter family. Conjugate transporter (TC 3.A.1.208) subfamily.,similarity:Contains 2 ABC transmembrane type-1 domains.,similarity:Contains 2 ABC transporter domains.,tissue specificity:Isoform 1 is specifically expressed in spleen. Isoform 2 is more widely expressed.,
Subcellular Location：Cell membrane ; Multi-pass membrane protein . Basolateral cell membrane ; Multi-pass membrane protein .
Expression：[Isoform 1]: Specifically expressed in spleen. ; [Isoform 2]: Widely expressed.
