Target：MRP3

Fields：Antifolate resistance;ABC transporters;Bile secretion

Gene Name：ABCC3

Protein Name：Canalicular multispecific organic anion transporter 2

Human Gene Id：8714

Human Swiss Prot No：O15438

Mouse Swiss Prot No：B2RX12

Immunogen：The antiserum was produced against synthesized peptide derived from human ABCC3. AA range:971-1020

Specificity：MRP3 Polyclonal Antibody detects endogenous levels of MRP3 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ABCC3;CMOAT2;MLP2;MRP3;Canalicular multispecific organic anion transporter 2;ATP-binding cassette sub-family C member 3;Multi-specific organic anion transporter D;MOAT-D;Multidrug resistance-associated protein 3

Observed Band(KD)：170kD

Background： The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008],

Function：alternative products:Additional isoforms seem to exist,function:May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes.,similarity:Belongs to the ABC transporter family.,similarity:Belongs to the ABC transporter family. Conjugate transporter (TC 3.A.1.208) subfamily.,similarity:Contains 2 ABC transmembrane type-1 domains.,similarity:Contains 2 ABC transporter domains.,tissue specificity:Mainly expressed in the liver. Also expressed in small intestine, colon, prostate, testis, brain and at a lower level in the kidney.,

Subcellular Location：Basolateral cell membrane ; Multi-pass membrane protein .

Expression：Mainly expressed in the liver. Also expressed in small intestine, colon, prostate, testis, brain and at a lower level in the kidney.