Target：MRP2

Fields：Antifolate resistance;Platinum drug resistance;ABC transporters;Bile secretion

Gene Name：ABCC2

Protein Name：Canalicular multispecific organic anion transporter 1

Human Gene Id：1244

Human Swiss Prot No：Q92887

Mouse Swiss Prot No：Q8VI47

Immunogen：The antiserum was produced against synthesized peptide derived from human ABCC2. AA range:991-1040

Specificity：MRP2 Polyclonal Antibody detects endogenous levels of MRP2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ABCC2;CMOAT;CMOAT1;CMRP;MRP2;Canalicular multispecific organic anion transporter 1;ATP-binding cassette sub-family C member 2;Canalicular multidrug resistance protein;Multidrug resistance-associated protein 2

Molecular Weight(Da)：175kD

Observed Band(KD)：190-250kD

Background： The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008],

Function：disease:Defects in ABCC2 are the cause of Dubin-Johnson syndrome (DJS) [MIM:237500]. DJS is an autosomal recessive disorder characterized by conjugated hyperbilirubinemia, an increase in the urinary excretion of coproporphyrin isomer I, deposition of melanin-like pigment in hepatocytes, and prolonged retention of sulfobromophthalein, but otherwise normal liver function.,function:Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.,similarity:Belongs to the ABC transporter family. Conjugate transporter (TC 3.A.1.208) subfamily.,similarity:Contains 2 ABC transmembrane type-1 domains.,similarity:Contains 2 ABC transporter domains.,tissue specificity:Found on the apical membrane of polarized cells in liver, kidney and intestine. The highest expression is found in liver.,

Subcellular Location：Apical cell membrane ; Multi-pass membrane protein .

Expression：Expressed by polarized cells in liver, kidney and intestine. The highest expression is found in liver.