Target:MRGX1
Gene Name:MRGPRX1
Protein Name:Mas-related G-protein coupled receptor member X1
Human Gene Id:259249
Human Swiss Prot No:Q96LB2
Mouse Swiss Prot No:Q8CIP3
Immunogen:The antiserum was produced against synthesized peptide derived from human MRGX1. AA range:271-320
Specificity:MRGX1 Polyclonal Antibody detects endogenous levels of MRGX1 protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500-2000;IHC 1:50-300
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:MRGPRX1;MRGX1;SNSR3;SNSR4;Mas-related G-protein coupled receptor member X1;Sensory neuron-specific G-protein coupled receptor 3/4
Observed Band(KD):36kD
Background:function:Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway.,similarity:Belongs to the G-protein coupled receptor 1 family. Mas subfamily.,tissue specificity:Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons.,
Function:function:Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway.,similarity:Belongs to the G-protein coupled receptor 1 family. Mas subfamily.,tissue specificity:Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons.,
Subcellular Location:Cell membrane; Multi-pass membrane protein.
Expression:Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons.