Target：MPRD

Fields：Lysosome;Phagosome;Salmonella infection

Gene Name：M6PR MPR46 MPRD

Protein Name：Cation-dependent mannose-6-phosphate receptor (CD Man-6-P receptor) (CD-MPR) (46 kDa mannose 6-phosphate receptor) (MPR 46)

Human Gene Id：4074

Human Swiss Prot No：P20645

Mouse Swiss Prot No：P24668

Rat Swiss Prot No：Q6AY20

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：MPRD Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：30kD

Background： This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, May 2011],

Function：domain:The extracellular domain is homologous to the repeating units (of approximately 147 AA) of the cation-independent mannose 6-phosphate receptor.,function:Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.,miscellaneous:This receptor has optimal binding in the presence of divalent cations.,subunit:Homodimer. Binds GGA1, GGA2 and GGA3.,

Subcellular Location：Lysosome membrane; Single-pass type I membrane protein.

Expression： Leukocyte,Liver,Muscle,Uterus,