Target：MOT4
Fields：Central carbon metabolism in cancer
Gene Name：SLC16A3 MCT4
Protein Name：Monocarboxylate transporter 4 (MCT 4) (Solute carrier family 16 member 3)
Human Gene Id：9123
Human Swiss Prot No：O15427
Mouse Gene Id：80879
Mouse Swiss Prot No：P57787
Rat Gene Id：80878
Rat Swiss Prot No：O35910
Immunogen：Synthesized peptide derived from human MOT4 Polyclonal
Specificity：This antibody detects endogenous levels of MOT4.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：Monocarboxylate transporter 4 (MCT 4) (Solute carrier family 16 member 3)
Observed Band(KD)：50kD
Background： Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton-linked monocarboxylate transporter (MCT) family, which has been designated solute carrier family-16. Each MCT appears to have slightly different substrate and inhibitor specificities and transport kinetics, which are related to the metabolic requirements of the tissues in which it is found. The MCTs, which include MCT1 (SLC16A1; MIM 600682) and MCT2 (SLC16A7; MIM 603654), are characterized by 12 predicted transmembrane domains (Price et al., 1998 [PubMed 9425115]).[supplied by OMIM, Mar 2008],
Function：function:Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate.,similarity:Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.,tissue specificity:Highly expressed in skeletal muscle.,
Subcellular Location：Cell membrane; Multi-pass membrane protein.
Expression：Highly expressed in skeletal muscle.
