Target：MOG

Gene Name：MOG

Protein Name：Myelin-oligodendrocyte glycoprotein

Human Gene Id：4340

Human Swiss Prot No：Q16653

Mouse Swiss Prot No：Q61885

Rat Swiss Prot No：Q63345

Immunogen：Synthesized peptide derived from human protein . at AA range: 30-110

Specificity：MOG Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：27kD

Background： The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],

Function：alternative products:Additional isoforms seem to exist,caution:Do not confuse myelin-oligodendrocyte glycoprotein (MOG) with oligodendrocyte-myelin glycoprotein (OMG).,function:Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication.,online information:Myelin oligodendrocyte glycoprotein entry,similarity:Belongs to the immunoglobulin superfamily. BTN/MOG family.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:May form homo- or heterodimers between the different isoforms.,tissue specificity:Found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes.,

Subcellular Location：[Isoform 1]: Cell membrane ; Multi-pass membrane protein .; [Isoform 5]: Cell membrane ; Multi-pass membrane protein .; [Isoform 2]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 3]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 4]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 6]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 7]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 8]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 9]: Cell membrane ; Single-pass type I membrane protein .

Expression：Found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes.