Target：MOAP1

Gene Name：MOAP1 PNMA4

Protein Name：Modulator of apoptosis 1 (MAP-1) (MAP1) (Paraneoplastic antigen Ma4)

Human Gene Id：64112

Human Swiss Prot No：Q96BY2

Mouse Swiss Prot No：Q9ERH6

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：MOAP1 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：38kD

Background：modulator of apoptosis 1(MOAP1) Homo sapiens The protein encoded by this gene was identified by its interaction with apoptosis regulator BAX protein. This protein contains a Bcl-2 homology 3 (BH3)-like motif, which is required for the association with BAX. When overexpressed, this gene has been shown to mediate caspase-dependent apoptosis. [provided by RefSeq, Jul 2008],

Function：domain:The BH3-like domain is required for association with BAX and for mediating apoptosis. The three BH domains (BH1, BH2, and BH3) of BAX are all required for mediating protein-protein interaction.,function:Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation.,similarity:Belongs to the PNMA family.,subunit:Homodimer. Under normal circumstances, held in an inactive conformation by an intramolecular interaction. Binding to RASSF1 isoform A (RASSF1A) relieves this inhibitory interaction and allows further binding to BAX. Binds also to BCL2 and BCLX. Recruited to the TNFRSF1A and TNFRSF10A complexes in response to their respective cognate ligand, after internalization.,tissue specificity:Ubiquitously expressed with higher levels in heart and b

Subcellular Location：Cytoplasm, cytosol . Mitochondrion outer membrane . Extracellular vesicle membrane . Forms virion-like extracellular vesicles that are released from cells. .

Expression：Widely expressed, with high levels in heart and brain.