Target：MNT

Gene Name：MNT

Protein Name：Max-binding protein MNT

Human Gene Id：4335

Human Swiss Prot No：Q99583

Mouse Swiss Prot No：O08789

Immunogen：The antiserum was produced against synthesized peptide derived from human MNT. AA range:315-364

Specificity：MNT Polyclonal Antibody detects endogenous levels of MNT protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：MNT;BHLHD3;ROX;Max-binding protein MNT;Class D basic helix-loop-helix protein 3;bHLHd3;Myc antagonist MNT;Protein ROX

Observed Band(KD)：62kD

Background： The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain. [provided by RefSeq, Jul 2008],

Function：function:Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as an homodimer or a heterodimer with MAX.,

Subcellular Location：Nucleus.

Expression： Fetal brain,Pancreas,