Target：OB-cadherin
Gene Name：CDH11
Protein Name：Cadherin-11
Human Gene Id：1009
Human Swiss Prot No：P55287
Mouse Gene Id：12552
Mouse Swiss Prot No：P55288
Immunogen：The antiserum was produced against synthesized peptide derived from human CDH11. AA range:421-470
Specificity：OB-cadherin Polyclonal Antibody detects endogenous levels of OB-cadherin protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：CDH11;Cadherin-11;OSF-4;Osteoblast cadherin;OB-cadherin
Observed Band(KD)：85kD
Background： This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance. [provided by RefSeq, Jul 2008],
Function：function:Cadherins are calcium dependent cell adhesion proteins.,function:Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.,similarity:Contains 5 cadherin domains.,tissue specificity:Expressed mainly in brain but also found in other tissues. Expressed in neuroblasts.,
Subcellular Location：Cell membrane; Single-pass type I membrane protein.
Expression：Expressed mainly in brain but also found in other tissues. Expressed in neuroblasts.
