Target：Plasminogen receptor

Gene Name：PLGRKT

Protein Name：Plasminogen receptor

Human Gene Id：55848

Human Swiss Prot No：Q9HBL7

Mouse Gene Id：67759

Mouse Swiss Prot No：Q9D3P8

Rat Swiss Prot No：D4ACN8

Immunogen：The antiserum was produced against synthesized peptide derived from the Internal region of human PLGRKT. AA range:1-50

Specificity：Plasminogen receptor Polyclonal Antibody detects endogenous levels of Plasminogen receptor

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：Plasminogen receptor (KT) (Plg-R(KT))

Observed Band(KD)：17kD

Background：Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells. Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo.

Subcellular Location：Cell membrane ; Multi-pass membrane protein . Colocalizes on the cell surface with urokinase plasminogen activator surface receptor/PLAUR. .

Expression：Expressed in peripheral blood cells and monocytes. Expressed in adrenal medulla.