Target:PLCβ3
Fields:Inositol phosphate metabolism;Metabolic pathways;Rap1 signaling pathway;Calcium signaling pathway;cGMP-PKG signaling pathway;Chemokine signaling pathway;Phosphatidylinositol signaling system;Sphingolipid signaling pathway;Phospholipase D signaling pathway;Adrenergic signaling in cardiomyocytes;Vascular smooth muscle contraction;Wnt signaling pathway;Apelin signaling pathway;Gap junction;Platelet activation;Neutrophil extracellular trap formation;NOD-like receptor signaling pathway;Circadian entrainment;Long-term potentiation;Retrograde endocannabinoid signaling;Glutamatergic synapse;Cholinergic synapse;Serotonergic synapse;Dopaminergic synapse;Long-term depression;Taste transduction;Inflammatory mediator regulation of TRP channels;Insulin secretion;GnRH signaling pathway;Estrogen signaling pathway;Melanogenesis;Thyroid hormone synthesis;Thyroid hormone signaling pathway;Oxytocin signaling pathway;Glucagon signaling p
Gene Name:PLCB3
Protein Name:1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
Human Gene Id:5331
Human Swiss Prot No:Q01970
Mouse Swiss Prot No:P51432
Rat Swiss Prot No:Q99JE6
Immunogen:The antiserum was produced against synthesized peptide derived from human PLC beta3. AA range:503-552
Specificity:PLC β3 Polyclonal Antibody detects endogenous levels of PLC β3 protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:PLCB3;1-phosphatidylinositol 4;5-bisphosphate phosphodiesterase beta-3;Phosphoinositide phospholipase C-beta-3;Phospholipase C-beta-3;PLC-beta-3
Observed Band(KD):140kD
Background: This gene encodes a member of the phosphoinositide phospholipase C beta enzyme family that catalyze the production of the secondary messengers diacylglycerol and inositol 1,4,5-triphosphate from phosphatidylinositol in G-protein-linked receptor-mediated signal transduction. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010],
Function:catalytic activity:1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.,cofactor:Calcium.,function:The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.,similarity:Contains 1 C2 domain.,similarity:Contains 1 PI-PLC X-box domain.,similarity:Contains 1 PI-PLC Y-box domain.,subunit:Interacts with SHANK2 (By similarity). Interacts with LPAR2.,
Subcellular Location:Cytoplasm . Membrane . Nucleus . And particulate fractions. .
Expression: Epithelium,Uterus,