Target：PLC β2

Fields：Inositol phosphate metabolism;Metabolic pathways;Rap1 signaling pathway;Calcium signaling pathway;cGMP-PKG signaling pathway;Chemokine signaling pathway;Phosphatidylinositol signaling system;Sphingolipid signaling pathway;Phospholipase D signaling pathway;Adrenergic signaling in cardiomyocytes;Vascular smooth muscle contraction;Wnt signaling pathway;Apelin signaling pathway;Gap junction;Platelet activation;Neutrophil extracellular trap formation;NOD-like receptor signaling pathway;Circadian entrainment;Long-term potentiation;Retrograde endocannabinoid signaling;Glutamatergic synapse;Cholinergic synapse;Serotonergic synapse;Dopaminergic synapse;Long-term depression;Taste transduction;Inflammatory mediator regulation of TRP channels;Insulin secretion;GnRH signaling pathway;Estrogen signaling pathway;Melanogenesis;Thyroid hormone synthesis;Thyroid hormone signaling pathway;Oxytocin signaling pathway;Glucagon signaling p

Gene Name：PLCB2

Protein Name：1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2

Human Gene Id：5330

Human Swiss Prot No：Q00722

Mouse Gene Id：18796

Mouse Swiss Prot No：A3KGF7

Rat Gene Id：85240

Rat Swiss Prot No：O89040

Immunogen：Synthesized peptide derived from the Internal region of human PLC β2.

Specificity：PLC β2 Polyclonal Antibody detects endogenous levels of PLC β2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：PLCB2;1-phosphatidylinositol 4;5-bisphosphate phosphodiesterase beta-2;Phosphoinositide phospholipase C-beta-2;Phospholipase C-beta-2;PLC-beta-2

Observed Band(KD)：150kD

Background：catalytic activity:1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.,cofactor:Binds 1 calcium ion per subunit.,function:The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.,miscellaneous:The receptor-mediated activation of PLC-beta-2 is most effectively mediated by one G-protein alpha subunit, alpha-16.,similarity:Contains 1 C2 domain.,similarity:Contains 1 PI-PLC X-box domain.,similarity:Contains 1 PI-PLC Y-box domain.,subunit:Interacts with RAC1.,

Function：catalytic activity:1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.,cofactor:Binds 1 calcium ion per subunit.,function:The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.,miscellaneous:The receptor-mediated activation of PLC-beta-2 is most effectively mediated by one G-protein alpha subunit, alpha-16.,similarity:Contains 1 C2 domain.,similarity:Contains 1 PI-PLC X-box domain.,similarity:Contains 1 PI-PLC Y-box domain.,subunit:Interacts with RAC1.,

Subcellular Location：intracellular,cytosol,

Expression： Placenta,Spleen,Thymus,