Target：OAT

Fields：Arginine and proline metabolism;Metabolic pathways

Gene Name：OAT

Protein Name：Ornithine aminotransferase mitochondrial

Human Gene Id：4942

Human Swiss Prot No：P04181

Mouse Gene Id：18242

Mouse Swiss Prot No：P29758

Rat Gene Id：64313

Rat Swiss Prot No：P04182

Immunogen：Synthesized peptide derived from OAT . at AA range: 100-180

Specificity：OAT Polyclonal Antibody detects endogenous levels of OAT protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：OAT;Ornithine aminotransferase; mitochondrial;Ornithine delta-aminotransferase;Ornithine--oxo-acid aminotransferase

Observed Band(KD)：48kD

Background：ornithine aminotransferase(OAT) Homo sapiens This gene encodes the mitochondrial enzyme ornithine aminotransferase, which is a key enzyme in the pathway that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA. Mutations that result in a deficiency of this enzyme cause the autosomal recessive eye disease Gyrate Atrophy. Alternatively spliced transcript variants encoding different isoforms have been described. Related pseudogenes have been defined on the X chromosome. [provided by RefSeq, Jan 2010],

Function：catalytic activity:L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid.,cofactor:Pyridoxal phosphate.,disease:Defects in OAT are the cause of hyperornithinemia with gyrate atrophy of choroid and retina (HOGA) [MIM:258870]. HOGA is a slowly progressive blinding autosomal recessive disorder.,pathway:Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.,similarity:Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.,subunit:Homotetramer.,

Subcellular Location：Mitochondrion matrix .

Expression： Alzheimer cortex,Brain,Cerebral cortex,Kidney,Liver,Placenta,Subthalamic nucleus,Ut