Target：Ox40

Fields：Cytokine-cytokine receptor interaction

Gene Name：TNFRSF4

Protein Name：Tumor necrosis factor receptor superfamily member 4

Human Gene Id：7293

Human Swiss Prot No：P43489

Mouse Swiss Prot No：P47741

Immunogen：The antiserum was produced against synthesized peptide derived from the Internal region of human TNFRSF4. AA range:131-180

Specificity：Ox40 Polyclonal Antibody detects endogenous levels of Ox40 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：TNFRSF4;TXGP1L;Tumor necrosis factor receptor superfamily member 4;ACT35 antigen;OX40L receptor;TAX transcriptionally-activated glycoprotein 1 receptor;CD134

Observed Band(KD)：30kD

Background： The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008],

Function：function:Receptor for TNFSF4/OX40L/GP34.,similarity:Contains 4 TNFR-Cys repeats.,subunit:Interacts with TRAF2, TRAF3 and TRAF5.,

Subcellular Location：Membrane; Single-pass type I membrane protein.

Expression： Brain,