Target：Fyb

Fields：Rap1 signaling pathway;Yersinia infection

Gene Name：FYB

Protein Name：FYN-binding protein

Human Gene Id：2533

Human Swiss Prot No：O15117

Mouse Gene Id：23880

Mouse Swiss Prot No：O35601

Immunogen：Synthesized peptide derived from Fyb . at AA range: 620-700

Specificity：Fyb Polyclonal Antibody detects endogenous levels of Fyb protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：FYB;SLAP130;FYN-binding protein;Adhesion and degranulation promoting adaptor protein;ADAP;FYB-120/130;p120/p130;FYN-T-binding protein;SLAP-130;SLP-76-associated phosphoprotein

Observed Band(KD)：85kD

Background： The protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T-cells. The encoded protein is involved in platelet activation and controls the expression of interleukin-2. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011],

Function：function:Acts as an adapter protein of the FYN and LCP2 signaling cascades in T cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2.,PTM:T-cell receptor ligation leads to increased tyrosine phosphorylation.,similarity:Contains 1 SH3 domain.,subunit:Part of a complex consisting of SKAP2, FYB and PTPNS1. Part of a complex consisting of SKAP2, FYB and LILRB3 (By similarity). Interacts with FYN, LCP2, SKAP1 and SKAP2.,tissue specificity:Expressed in hematopoietic tissues such as myeloid and T-cells, spleen and thymus. Not expressed in B-cells, nor in non-lymphoid tissues.,

Subcellular Location：Cytoplasm . Nucleus . Cell junction . Colocalizes with TMEM47 at cell-cell contacts in podocytes. .

Expression：Expressed in hematopoietic tissues such as myeloid and T-cells, spleen and thymus. Not expressed in B-cells, nor in non-lymphoid tissues.