Target：PA24B

Fields：Glycerophospholipid metabolism;Ether lipid metabolism;Arachidonic acid metabolism;Linoleic acid metabolism;alpha-Linolenic acid metabolism;Metabolic pathways;MAPK signaling pathway;Ras signaling pathway;Phospholipase D signaling pathway;Necroptosis;Vascular smooth muscle contraction;VEGF signaling pathway;Platelet activation;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Glutamatergic synapse;Serotonergic synapse;Long-term depression;Inflammatory mediator regulation of TRP channels;GnRH signaling pathway;Ovarian steroidogenesis;Oxytocin signaling pathway;Choline metabolism in cancer

Gene Name：PLA2G4B

Protein Name：Cytosolic phospholipase A2 beta (cPLA2-beta) (EC 3.1.1.4) (Phospholipase A2 group IVB)

Human Gene Id：100137049

Human Swiss Prot No：P0C869

Mouse Swiss Prot No：P0C871

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：PA24B Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：85kD

Background： This locus represents naturally-occurring readthrough transcription between the neighboring jumonji domain containing 7 (JMJD7) and phospholipase A2, group IVB (cytosolic) (PLA2G4B) genes. Readthrough transcripts encode fusion proteins that share amino acid sequence with each individual gene product, including a partial JmjC domain and downstream C2 and phospholipase A2 domains. Alternatively spliced transcript variants have been observed. [provided by RefSeq, Oct 2013],

Function：catalytic activity:Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.,caution:Most tissues also express read-through transcripts from this gene into the upstream gene (Jmjd7), some of which may encode fusion proteins.,caution:This sequence was first thought to be an alternatively spliced isoform of Pla2g4b. It is derived from Jmjd7 which is located upstream of Pla2g4b. Most tissues also express read-through transcripts from Jmjd7 into the downstream Pla2g4b gene, some of which may encode fusion proteins combining the N-terminus of this protein with PLA2G4B protein.,domain:The N-terminal C2 domain associates with lipid membranes and mediates its regulation by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+).,enzyme regulation:Stimulated by cytosolic Ca(2+).,function:Calcium-dependent phospholipase A2 that selectively hydroly

Subcellular Location：[Isoform 3]: Cytoplasm, cytosol . Mitochondrion membrane ; Peripheral membrane protein. Early endosome membrane ; Peripheral membrane protein. Translocates to membrane vesicles in a calcium-dependent fashion. .; [Isoform 5]: Cytoplasm, cytosol .

Expression：Widely expressed. Expressed at higher level in brain, heart, liver, cerebellum and pancreas.