Target：p52 S6 kinase

Gene Name：RPS6KC1

Protein Name：Ribosomal protein S6 kinase delta-1

Human Gene Id：26750

Human Swiss Prot No：Q96S38

Mouse Gene Id：320119

Mouse Swiss Prot No：Q8BLK9

Immunogen：The antiserum was produced against synthesized peptide derived from human RPS6KC1. AA range:231-280

Specificity：p52 S6 kinase Polyclonal Antibody detects endogenous levels of p52 S6 kinase protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：RPS6KC1;RPK118;Ribosomal protein S6 kinase delta-1;S6K-delta-1;52 kDa ribosomal protein S6 kinase;Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein;SPHK1-binding protein

Observed Band(KD)：117kD

Background：catalytic activity:ATP + a protein = ADP + a phosphoprotein.,caution:Instead of Lys-820, Arg-820 is found at the binding site.,domain:The first protein kinase domain appears to be a pseudokinase domain as it does not contain the classical characteristics, such as the ATP-binding motif, ATP-binding site and active site.,function:May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. S6 kinase subfamily.,similarity:Contains 1 MIT domain.,similarity:Contains 1 PX (phox homology) domain.,similarity:Contains 2 protein kinase domains.,subcellular location:Also found in some small dot-like or ring-shaped early endosome structures.,subunit:Interacts with SPHK1 and phosphatidylinositol 3-phosphate.,tissue specificity:Highly expressed in testis, skeletal muscle, brain, heart, placenta, kidney and liver and weakly expressed in thymus, small intestine, lung and colon.,

Function：catalytic activity:ATP + a protein = ADP + a phosphoprotein.,caution:Instead of Lys-820, Arg-820 is found at the binding site.,domain:The first protein kinase domain appears to be a pseudokinase domain as it does not contain the classical characteristics, such as the ATP-binding motif, ATP-binding site and active site.,function:May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. S6 kinase subfamily.,similarity:Contains 1 MIT domain.,similarity:Contains 1 PX (phox homology) domain.,similarity:Contains 2 protein kinase domains.,subcellular location:Also found in some small dot-like or ring-shaped early endosome structures.,subunit:Interacts with SPHK1 and phosphatidylinositol 3-phosphate.,tissue specificity:Highly expressed in testis, skeletal muscle, brain, hear

Subcellular Location：Cytoplasm . Membrane . Early endosome .

Expression：Highly expressed in testis, skeletal muscle, brain, heart, placenta, kidney and liver and weakly expressed in thymus, small intestine, lung and colon.