Target:PAR-6β
Fields:Rap1 signaling pathway;Endocytosis;Axon guidance;Hippo signaling pathway;Tight junction;Human papillomavirus infection
Gene Name:PARD6B
Protein Name:Partitioning defective 6 homolog beta
Human Gene Id:84612
Human Swiss Prot No:Q9BYG5
Mouse Gene Id:58220
Mouse Swiss Prot No:Q9JK83
Immunogen:The antiserum was produced against synthesized peptide derived from human PARD6B. AA range:233-282
Specificity:PAR-6β Polyclonal Antibody detects endogenous levels of PAR-6β protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:PARD6B;PAR6B;Partitioning defective 6 homolog beta;PAR-6 beta;PAR-6B
Observed Band(KD):38kD
Background: This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. [provided by RefSeq, Jul 2008],
Function:domain:The PDZ domain mediates interaction with MPP5.,domain:The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases.,function:Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.,similarity:Belongs to the PAR6 family.,similarity:Contains 1 OPR domain.,similarity:Contains 1 PDZ (DHR) domain.,similarity:Contains 1 pseudo-CRIB domain.,subunit:Interacts with PARD3. Interacts with GTP-bound forms of CDC42 and RAC1. Interacts with GTP-bound ARHQ/TC10. Interacts with MPP5 (By similarity). Interacts with the N-terminal part of PRKCI and
Subcellular Location:Cytoplasm. Cell membrane . Cell junction, tight junction .
Expression:Expressed in pancreas and in both adult and fetal kidney. Weakly expressed in placenta and lung. Not expressed in other tissues.