Target：TReP-132
Gene Name：TRERF1
Protein Name：Transcriptional-regulating factor 1
Human Gene Id：55809
Human Swiss Prot No：Q96PN7
Mouse Gene Id：224829
Mouse Swiss Prot No：Q8BXJ2
Immunogen：The antiserum was produced against synthesized peptide derived from human TREF1. AA range:1071-1120
Specificity：TReP-132 Polyclonal Antibody detects endogenous levels of TReP-132 protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：TRERF1;BCAR2;RAPA;TREP132;Transcriptional-regulating factor 1;Breast cancer anti-estrogen resistance 2;Transcriptional-regulating protein 132;Zinc finger protein rapa;Zinc finger transcription factor TReP-132
Molecular Weight(Da)：132kD
Background： This gene encodes a zinc-finger transcriptional regulating protein which interacts with CBP/p300 to regulate the human gene CYP11A1. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014],
Function：function:Activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1.,similarity:Contains 1 ELM2 domain.,similarity:Contains 1 SANT domain.,similarity:Contains 3 C2H2-type zinc fingers.,subunit:Interacts with CREBBP and EP300.,tissue specificity:Highest expression was seen in thymus, testis and adrenal cortex, expressed also in the adrenal medulla, thyroid, and stomach. Highly expressed in steroidogenic JEG-3 and MCF-7 cells, low expression was seen in non-steroidogenic HepG2 and HK293 cells.,
Subcellular Location：Nucleus .
Expression：Highest expression was seen in thymus, testis and adrenal cortex, expressed also in the adrenal medulla, thyroid, and stomach. Highly expressed in steroidogenic JEG-3 and MCF-7 cells, low expression was seen in non-steroidogenic Hep-G2 and HEK293 cells.
