Target：PDGF-A

Fields：EGFR tyrosine kinase inhibitor resistance;MAPK signaling pathway;Ras signaling pathway;Rap1 signaling pathway;Calcium signaling pathway;Phospholipase D signaling pathway;PI3K-Akt signaling pathway;Focal adhesion;Gap junction;JAK-STAT signaling pathway;Regulation of actin cytoskeleton;Pathways in cancer;Transcriptional misregulation in cancer;MicroRNAs in cancer;Glioma;Prostate cancer;Melanoma;Choline metabolism in cancer;Fluid shear stress and atherosclerosis

Gene Name：PDGFA

Protein Name：Platelet-derived growth factor subunit A

Human Gene Id：5154

Human Swiss Prot No：P04085

Mouse Gene Id：18590

Mouse Swiss Prot No：P20033

Rat Gene Id：25266

Rat Swiss Prot No：P28576

Immunogen：The antiserum was produced against synthesized peptide derived from human PDGF-A. AA range:105-154

Specificity：PDGF-A Polyclonal Antibody detects endogenous levels of PDGF-A protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：PDGFA;PDGF1;Platelet-derived growth factor subunit A;PDGF subunit A;PDGF-1;Platelet-derived growth factor A chain;Platelet-derived growth factor alpha polypeptide

Observed Band(KD)：17kD

Background：platelet derived growth factor subunit A(PDGFA) Homo sapiens This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015],

Function：domain:The long form contains a basic insert which acts as a cell retention signal.,function:Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. It is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound.,miscellaneous:A-A and B-B, as well as A-B, dimers can bind to the PDGF receptor.,similarity:Belongs to the PDGF/VEGF growth factor family.,subunit:Antiparallel disulfide-linked dimer of non-identical (A and B) chains. Homodimers of A and B chains are implicated in transformation processes. Interacts with CSPG4.,

Subcellular Location：Secreted. Released by platelets upon wounding.

Expression： PCR rescued clones,