Target：PD-ECGF

Fields：Pyrimidine metabolism;Drug metabolism - other enzymes;Metabolic pathways;Nucleotide metabolism;Bladder cancer

Gene Name：TYMP

Protein Name：Thymidine phosphorylase

Human Gene Id：1890

Human Swiss Prot No：P19971

Mouse Gene Id：72962

Mouse Swiss Prot No：Q99N42

Rat Gene Id：315219

Rat Swiss Prot No：Q5FVR2

Immunogen：The antiserum was produced against synthesized peptide derived from the N-terminal region of human TYMP. AA range:11-60

Specificity：PD-ECGF Polyclonal Antibody detects endogenous levels of PD-ECGF protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：TYMP;ECGF1;Thymidine phosphorylase;TP;Gliostatin;Platelet-derived endothelial cell growth factor;PD-ECGF;TdRPase

Observed Band(KD)：50kD

Background： This gene encodes an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. It has a highly restricted target cell specificity acting only on endothelial cells. Mutations in this gene have been associated with mitochondrial neurogastrointestinal encephalomyopathy. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Apr 2012],

Function：catalytic activity:Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.,disease:Defects in TYMP are the cause of mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) [MIM:603041]; also known as myoneurogastrointestinal encephalomyopathy. MNGIE is an autosomal recessive disease associated with multiple deletions of skeletal muscle mitochondrial DNA (MtDNA). It is clinically characterized by onset between the second and fifth decades of life, ptosis, progressive external ophthalmoplegia, gastrointestinal dysmotility (often pseudoobstruction), diffuse leukoencephalopathy, thin body habitus, peripheral neuropathy, and myopathy.,function:Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.,function:May have a role in maintaining the in

Subcellular Location：cytosol,

Expression： Brain,Lung,Placenta,Synovial membrane tissue,