Target：PDE1A

Fields：Purine metabolism;Metabolic pathways;Calcium signaling pathway;Olfactory transduction;Taste transduction;Renin secretion;Morphine addiction

Gene Name：PDE1A

Protein Name：Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (Cam-PDE 1A) (EC 3.1.4.17) (61 kDa Cam-PDE) (hCam-1)

Human Gene Id：5136

Human Swiss Prot No：P54750

Mouse Swiss Prot No：Q61481

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：PDE1A Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：58kD

Background： Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001 [PubMed 11342109]; Fidock et al., 2002 [PubMed 11747989]).[supplied by OMIM, Oct 2009],

Function：catalytic activity:Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.,enzyme regulation:Type I PDE are activated by the binding of calmodulin in the presence of Ca(2+).,function:Has a higher affinity for cGMP than for cAMP.,similarity:Belongs to the cyclic nucleotide phosphodiesterase family.,subunit:Homodimer.,tissue specificity:Several tissues, including brain, kidney, testes and heart.,

Subcellular Location：nucleus,cytosol,neuronal cell body,

Expression：Several tissues, including brain, kidney, testes and heart.